SCHEMBL657069

SCHEMBL657069

O=C1CC(c2cccc3ccccc23)CC(=O)O1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.57
IDO1 P14902 1/20 0.49
PLA2G6 O60733 4/20 0.44
MAPK1 P28482 3/20 0.44
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
HPGD P15428 2/20 0.44
BLM P54132 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
FAAH O00519 1/20 0.44
NPC1 O15118 1/20 0.44
GMNN O75496 1/20 0.44
LMNA P02545 1/20 0.44
MTOR P42345 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TRPC5 Q9UL62 1/20 0.44
TRPC6 Q9Y210 1/20 0.44
KDM1A O60341 1/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16536751 0.86 MTNR1A (0.48) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL16536749 0.86 MTNR1A (0.48) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL562292 0.80 MTNR1A (0.58) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL7533164 0.79 PLA2G6 (0.56) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL576846 0.76 MTNR1A (0.50) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL30477104 0.74 SLC6A4 (0.59) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL248440 0.74 SLC6A4 (0.59) MTNR1AIDO1PLA2G6MAPK1ALDH1A1
SCHEMBL14580255 0.74 TP53 (0.65) MAPK1ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL657344 0.74 ALDH1A1 (0.50) ALDH1A1MAPTHPGD
SCHEMBL31121825 0.74 CTRB1 (0.47) ALDH1A1MAPTHPGDTP53HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0918754-B1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTAPHARM SPA (IT) 2007-12-05 EP claimed
US-6075033-A Anthranilic acid diamides derivatives, their preparation and pharmaceutical use as anti-gastrin agents ROTTA RESEARCH LABORATORIUM S.P.A (IT) 2000-06-13 US claimed
EP-0918754-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-06-02 EP claimed
WO-1998000404-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-01-08 WO claimed
EP-2349999-B1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIV SAARLAND (DE) 2016-01-27 EP disclosed
US-8912186-B2 Allosteric protein kinase modulators UNIVERSITAET DES SAARLANDES (DE) 2014-12-16 US disclosed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 US disclosed
EP-2349999-A1 ALLOSTERIC PROTEIN KINASE MODULATORS Universität des Saarlandes (DE) 2011-08-03 EP disclosed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 WO disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP disclosed
EP-0918754-B1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTAPHARM SPA (IT) 2007-12-05 EP disclosed
EP-0839137-B1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LAB (IT) 2001-08-16 EP disclosed
US-6075033-A Anthranilic acid diamides derivatives, their preparation and pharmaceutical use as anti-gastrin agents ROTTA RESEARCH LABORATORIUM S.P.A (IT) 2000-06-13 US disclosed
US-5922875-A ANTIULCER AGENTS, ANTITUMOR AGENTS TREATING GASTROINTESTINAL DISORDER, CENTRAL NERVOUS SYSTEM DISORDER LINKED TO IMBALANCES IN THE NEURAL PHYSIOLOGICAL LEVELS OF GASTRIN OR OTHER BIOACTIVE POLYPEPTIDES, EYE INFLAMMATION CAUSED BY SURGERY ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-07-13 US disclosed
EP-0918754-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-06-02 EP disclosed
EP-0839137-A1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-05-06 EP disclosed
WO-1998000404-A1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-01-08 WO disclosed
WO-1997002248-A1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1997-01-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB MTNR1A 3219/4885IDO1 3325/4885PLA2G6 1645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.