Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16563915 | 0.91 | CYP1A2 (0.54) | HDAC8HDAC1HDAC6PYGLKMT2A | |
| SCHEMBL16563778 | 0.89 | KMT2A (0.43) | HDAC8HDAC1HDAC6KMT2AMEN1 | |
| SCHEMBL16563900 | 0.88 | MAPT (0.50) | KMT2AMEN1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL16563791 | 0.82 | POLB (0.53) | KMT2AMEN1POLBKDM4EALDH1A1 | |
| SCHEMBL16563623 | 0.77 | ALOX15 (0.42) | KMT2AMEN1CYP1A2POLBKDM4E | |
| SCHEMBL16564040 | 0.77 | ORAI1 (0.52) | KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL16563605 | 0.74 | MEN1 (0.45) | KMT2AMEN1CYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL16563767 | 0.74 | ALOX15 (0.44) | — | |
| SCHEMBL16564046 | 0.72 | P2RX7 (0.47) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL16563435 | 0.72 | NPC1 (0.48) | KMT2AMEN1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | claimed |
| EP-2848615-A1 | New pyrazole derivatives as CRAC channel modulators | Almirall, S.A. (ES) | 2015-03-18 | — | — | EP | disclosed |