Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PEX14 | O75381 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20751266 | 0.84 | MTNR1A (0.45) | MTNR1AALDH1A1SMN1; SMN2PLK1ADORA3 | |
| SCHEMBL20750985 | 0.72 | KDM4A (0.49) | MTNR1AADORA3ADORA2AADORA1CMA1 | |
| SCHEMBL20751136 | 0.72 | KDM4A (0.41) | MTNR1AALDH1A1MAPTKDM4AKDM4C | |
| SCHEMBL11508658 | 0.67 | MAPT (0.45) | MTNR1ASMN1; SMN2MAPTCMA1KDM4A | |
| SCHEMBL21201531 | 0.65 | HDAC1 (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL20751178 | 0.65 | MTNR1A (0.40) | MTNR1AALDH1A1PGRGAAPTGS1 | |
| Alpha-Naphthylacetate SCHEMBL28109043 | 0.64 | ALDH1A1 (0.64) | ALDH1A1PGRGAAPTGS1MAPK1 | |
| Alpha-Naphthylacetate SCHEMBL14715837 | 0.64 | ALDH1A1 (0.64) | ALDH1A1PGRGAAPTGS1MAPK1 | |
| Alpha-Naphthylacetate SCHEMBL27862836 | 0.64 | ALDH1A1 (0.64) | ALDH1A1PGRGAAPTGS1MAPK1 | |
| SCHEMBL16578532 | 0.63 | SLC6A3 (0.46) | MTNR1AALDH1A1PGRGAAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364226-B2 | Pyridazinone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-07-30 | — | — | US | disclosed |
| EP-3030549-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA INC (US) | 2019-02-20 | — | — | EP | disclosed |
| WO-2015038660-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2015-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364226-B2 | Pyridazinone compounds and uses thereof | PDXK, PNPO, PLPBP | MTNR1A 994/4885ALDH1A1 2151/4885PGR 2026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.