Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382412 | 0.85 | ALDH1A1 (0.53) | ALDH1A1POLBKDM4ENQO2CYP3A4 | |
| SCHEMBL7231586 | 0.83 | ALDH1A1 (0.56) | ALDH1A1POLBKDM4ENQO2HPGD | |
| SCHEMBL27769272 | 0.77 | L3MBTL1 (0.44) | ALDH1A1KDM4ENQO2HPGDCYP3A4 | |
| SCHEMBL27348365 | 0.77 | ABL1 (0.30) | — | |
| SCHEMBL19088238 | 0.77 | MAPK1 (0.39) | ALDH1A1POLBKDM4EHPGDCYP1A2 | |
| SCHEMBL13760004 | 0.76 | ALDH1A1 (0.42) | ALDH1A1POLBKDM4ENQO2HPGD | |
| SCHEMBL17878829 | 0.76 | ALDH1A1 (0.42) | ALDH1A1POLBKDM4ENQO2HPGD | |
| SCHEMBL17923133 | 0.76 | NOS1 (0.45) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| SCHEMBL8894323 | 0.74 | ALDH1A1 (0.46) | ALDH1A1POLBKDM4ENQO2HPGD | |
| SCHEMBL14842377 | 0.73 | NOS3 (0.54) | ALDH1A1POLBKDM4ENQO2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738634-B2 | Heterocyclic amide compound and herbicide | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-22 | — | — | US | disclosed |
| WO-2017117406-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2017-07-06 | — | — | WO | disclosed |
| US-20160221998-A1 | HETEROCYCLIC AMIDE COMPOUND AND HERBICIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2016-08-04 | — | — | US | disclosed |
| EP-3045455-A1 | HETEROCYCLIC AMIDE COMPOUND AND HERBICIDE | Syngenta Participations AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015037680-A1 | HETEROCYCLIC AMIDE COMPOUND AND HERBICIDE | 日産化学工業株式会社 (JP) | 2015-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221998-A1 | HETEROCYCLIC AMIDE COMPOUND AND HERBICIDE | GLRA1, RER1, H1-4 | ALDH1A1 318/4885GRM5 389/4885POLB 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.