Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | NMT2 | O60551 | 3/20 | 0.45 |
| ▸ | NMT1 | P30419 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | RYR2 | Q92736 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL418525 | 0.82 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E | |
| SCHEMBL17041364 | 0.81 | MAOB (0.56) | ALDH1A1GAASMN1; SMN2MAOBMAOA | |
| SCHEMBL25034012 | 0.80 | MTNR1A (0.54) | ALDH1A1GAASMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL11488472 | 0.79 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E | |
| SCHEMBL15856977 | 0.79 | NPC1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9808184 | 0.78 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E | |
| SCHEMBL5167250 | 0.78 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E | |
| SCHEMBL9348226 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E | |
| SCHEMBL5172139 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E | |
| SCHEMBL9770431 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAOBMAOAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9889111-B2 | Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile | OLATEC THERAPEUTICS LLC (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170105962-A1 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE | OLATEC THERAPEUTICS, INC. | 2017-04-20 | — | — | US | disclosed |
| US-20170105962-A1 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE | OLATEC THERAPEUTICS, INC. | 2017-04-20 | — | — | US | disclosed |
| US-9481644-B2 | Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile | OLATEC THERAPEUTICS LLC (US) | 2016-11-01 | — | — | US | disclosed |
| US-9481644-B2 | Pharmaceutical composition comprising omega-(arylsulfonyl)alkylnitrile | OLATEC THERAPEUTICS LLC (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150087701-A1 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE | OLATEC THERAPEUTICS, INC. | 2015-03-26 | — | — | US | disclosed |
| US-20150087701-A1 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE | OLATEC THERAPEUTICS, INC. | 2015-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087701-A1 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE | ALOX15B, FADS1, ALOX15 | ALDH1A1 1394/4885GAA 2289/4885SMN1; SMN2 1124/4885 |
| US-20170105962-A1 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE | ALOX15B, FADS1, ALOX15 | ALDH1A1 1394/4885GAA 2289/4885SMN1; SMN2 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.