Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768728 | 0.92 | PKM (0.44) | RECQLMAPTALDH1A1PKMHSD17B10 | |
| SCHEMBL9220188 | 0.75 | AADAT (0.47) | RECQLMAPTALDH1A1PKMHSD17B10 | |
| SCHEMBL30768469 | 0.73 | RECQL (0.36) | RECQLMAPTALDH1A1PKMHSD17B10 | |
| SCHEMBL1658215 | 0.72 | ADORA3 (0.43) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1552098 | 0.71 | RECQL (0.60) | RECQLMAPTALDH1A1HSD17B10BRD4 | |
| SCHEMBL1172524 | 0.70 | RECQL (0.58) | RECQLMAPTALDH1A1PKMHSD17B10 | |
| SCHEMBL6663384 | 0.70 | ELANE (0.55) | RECQLBRD4LMNAMEN1KMT2A | |
| SCHEMBL1658823 | 0.70 | CHEK1 (0.42) | ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL16978815 | 0.69 | TSHR (0.54) | RECQLMAPTALDH1A1PKMHSD17B10 | |
| SCHEMBL1169685 | 0.68 | RECQL (0.60) | RECQLMAPTALDH1A1PKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943224-B1 | ESTROGEN RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2011-07-27 | — | — | EP | disclosed |
| US-7923568-B2 | Estrogen receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-04-12 | — | — | US | disclosed |
| US-20100168188-A1 | Estrogen Receptor Modulators | MERCK SHARP & DOHME LLC | 2010-07-01 | — | — | US | disclosed |
| EP-1943224-A4 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1943224-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007089291-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168188-A1 | Estrogen Receptor Modulators | ESR2, GPER1, ESRRA | RECQL 4093/4885MAPT 99/4885ALDH1A1 1883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.