Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12485134 | 0.85 | GLO1 (0.54) | TSHRMEN1KMT2AGLO1STAT3 | |
| SCHEMBL7570382 | 0.82 | TSHR (0.75) | TSHRMEN1KMT2ACYP19A1PKM | |
| SCHEMBL3791578 | 0.81 | TSHR (0.74) | TSHRMEN1KMT2APKMHTR2C | |
| SCHEMBL14645850 | 0.81 | ALDH1A1 (0.65) | TSHRMEN1KMT2AGLO1STAT3 | |
| SCHEMBL29561322 | 0.81 | MAPT (0.60) | GLO1STAT3CYP19A1PKMHSD11B1 | |
| SCHEMBL7572129 | 0.79 | GLO1 (0.60) | GLO1STAT3CYP19A1ACLYKDM4E | |
| SCHEMBL7571206 | 0.79 | RECQL (0.69) | MEN1KMT2AGLO1STAT3CYP19A1 | |
| SCHEMBL1970942 | 0.79 | KMT2A (0.71) | TSHRMEN1KMT2APKMKDM4E | |
| SCHEMBL30557370 | 0.79 | TSHR (0.71) | TSHRMEN1KMT2APKMALDH1A1 | |
| SCHEMBL7592222 | 0.79 | TSHR (0.71) | TSHRMEN1KMT2APKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853532-B1 | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III | INST FARMAKOLOGII POLSKIEJ AKADEMII NAUK (PL) | 2020-12-09 | — | — | EP | disclosed |
| EP-2853532-A1 | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III | Instytut Farmakologii Polskiej Akademii Nauk (PL) | 2015-04-01 | — | — | EP | disclosed |