Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | MLNR | O43193 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL175081 | 0.82 | ALDH1A1 (0.62) | ALDH1A1LMNAGPR84HTR2CHTR2B | |
| Malonic Acid SCHEMBL173339 | 0.78 | HTR2C (0.45) | MLNRHTR2AHTR2CHTR2BCYP2D6 | |
| Glycolic Acid SCHEMBL174349 | 0.78 | HTR2C (0.45) | MLNRHTR2AHTR2CHTR2BCYP2D6 | |
| Succinic Acid SCHEMBL174914 | 0.78 | HTR2C (0.45) | ALDH1A1MLNRHTR2AHTR2CHTR2B | |
| SCHEMBL162032 | 0.77 | HTR2C (0.57) | MLNRHTR2AHTR2CHTR2BCYP2D6 | |
| Orotic Acid SCHEMBL162920 | 0.77 | ALDH1A1 (0.45) | ALDH1A1LMNAGPR84HTR2AHTR2C | |
| Bromide SCHEMBL174563 | 0.76 | HTR2C (0.55) | MLNRHTR2AHTR2CHTR2BCYP2D6 | |
| Adipic Acid SCHEMBL173690 | 0.76 | HTR2C (0.42) | MLNRHTR2AHTR2CHTR2BCYP2D6 | |
| Sulfuric Acid SCHEMBL174597 | 0.75 | MLNR (0.52) | MLNRHTR2AHTR2CHTR2BCYP2D6 | |
| Phosphoric Acid SCHEMBL174207 | 0.75 | HTR2C (0.47) | MLNRHTR2AHTR2CHTR2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |