Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL16597641 | 0.95 | TSHR (0.44) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL16597743 | 0.95 | TSHR (0.44) | TSHRRGS12LMNAHSD17B10BACE1 | |
| Silver SCHEMBL6905008 | 0.95 | TSHR (0.44) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL16597493 | 0.95 | TSHR (0.44) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL2184430 | 0.79 | TSHR (0.50) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL10677331 | 0.79 | TSHR (0.50) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL3501182 | 0.78 | TSHR (0.44) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL2064738 | 0.76 | TSHR (0.42) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL11628675 | 0.74 | TSHR (0.46) | TSHRRGS12LMNAHSD17B10BACE1 | |
| SCHEMBL5916254 | 0.73 | TSHR (0.39) | TSHRRGS12HSD17B10BACE1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3049422-B1 | INTUMESCENT COATINGS | MIPA SE (DE) | 2019-07-31 | — | — | EP | disclosed |
| EP-3049422-A1 | INTUMESCENT COATINGS | Universität Innsbruck (AT) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015042628-A1 | INTUMESCENT COATINGS | UNIVERSITÄT INNSBRUCK (AT) | 2015-04-02 | — | — | WO | disclosed |