Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677331 | 0.80 | TSHR (0.50) | TSHRRGS12HSD17B10BACE1TDP1 | |
| SCHEMBL11628675 | 0.80 | TSHR (0.46) | TSHRRGS12HSD17B10BACE1TDP1 | |
| Potassium Ion SCHEMBL16597641 | 0.78 | TSHR (0.44) | TSHRRGS12HSD17B10BACE1TDP1 | |
| SCHEMBL16597743 | 0.78 | TSHR (0.44) | TSHRRGS12HSD17B10BACE1TDP1 | |
| SCHEMBL5916254 | 0.78 | TSHR (0.39) | TSHRRGS12HSD17B10BACE1TDP1 | |
| SCHEMBL16597486 | 0.78 | TSHR (0.44) | TSHRRGS12HSD17B10BACE1TDP1 | |
| SCHEMBL16597493 | 0.78 | TSHR (0.44) | TSHRRGS12HSD17B10BACE1TDP1 | |
| SCHEMBL345502 | 0.77 | TSHR (0.42) | TSHRRGS12HSD17B10BACE1GAA | |
| SCHEMBL7934703 | 0.75 | HSD17B10 (0.41) | TSHRRGS12HSD17B10GAARBP4 | |
| SCHEMBL12189523 | 0.71 | TSHR (0.38) | TSHRRGS12HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158024-A1 | TRICYCLIC NECROSTATIN COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-06-20 | — | — | US | disclosed |
| US-8324262-B2 | Tricyclic necrostatin compounds | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100190836-A1 | Compounds, Screens, and Methods of Treatment | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-07-29 | — | — | US | disclosed |
| CN-101674826-A | Chemical compound, screening and Therapeutic Method | HARVARD COLLEGE | 2010-03-17 | — | — | CN | disclosed |
| EP-1968583-A2 | COMPOUNDS, SCREENS, AND METHODS OF TREATMENT | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-09-17 | — | — | EP | disclosed |
| US-7253201-B2 | Contacting cell derivatives for decreasing necrosis naphthoprazole derivative for decreasing necrosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-08-07 | — | — | US | disclosed |
| WO-2007075772-A2 | COMPOUNDS, SCREENS, AND METHODS OF TREATMENT | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20050131044-A1 | Contacting cell derivatives for decreasing necrosis naphthoprazole derivative for decreasing necrosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-06-16 | — | — | US | disclosed |
| US-6756394-B1 | Small molecule inhibitors of necrosis | PRESIDENT AND FELLOW OF HARVARD COLLEGE | 2004-06-29 | — | — | US | disclosed |
| WO-2001028493-A2 | SMALL MOLECULE INHIBITORS OF NECROSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190836-A1 | Compounds, Screens, and Methods of Treatment | NLN, HTRA2, CLN6 | TSHR 3450/4885RGS12 3946/4885HSD17B10 1163/4885 |
| US-20050131044-A1 | Contacting cell derivatives for decreasing necrosis naphthoprazole derivative for decreasing necrosis | CASP3, CASP4, BAX | TSHR 2470/4885RGS12 4462/4885HSD17B10 2000/4885 |
| US-20130158024-A1 | TRICYCLIC NECROSTATIN COMPOUNDS | HTRA2, AIFM1, BAD | TSHR 1712/4885RGS12 4288/4885HSD17B10 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.