Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6903826 | 0.72 | TGFBR1 (0.31) | RAF1BRAF | |
| SCHEMBL23648676 | 0.70 | LMNA (0.41) | RAF1BRAF | |
| SCHEMBL6903571 | 0.64 | TGFBR1 (0.30) | — | |
| SCHEMBL25365005 | 0.63 | MMP13 (0.34) | RAF1 | |
| SCHEMBL29523581 | 0.63 | MMP13 (0.34) | RAF1 | |
| SCHEMBL17869557 | 0.62 | SLC6A3 (0.35) | — | |
| SCHEMBL30212887 | 0.62 | CHRNA1 (0.35) | — | |
| SCHEMBL28871226 | 0.61 | BRD4 (0.31) | — | |
| SCHEMBL9919833 | 0.61 | OPRM1 (0.35) | — | |
| SCHEMBL25355763 | 0.60 | LMNA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488031-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |