Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13960945 | 0.86 | MDM2 (0.35) | MAPTALDH1A1RECQLBRD4KDM4E | |
| SCHEMBL13367642 | 0.85 | MAPT (0.39) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL16601598 | 0.85 | ALDH1A1 (0.40) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL13340926 | 0.84 | SLC9A1 (0.35) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL89089 | 0.82 | MAPT (0.43) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL13367651 | 0.82 | RXRA (0.43) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL15786429 | 0.82 | REN (0.38) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL15161226 | 0.77 | PDE3B (0.49) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL15786401 | 0.76 | MAPT (0.40) | MAPTHPGDTSHRNPSR1POLB | |
| SCHEMBL13091047 | 0.74 | ALDH1A1 (0.47) | MAPTHPGDTSHRNPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |