Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13091047 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPTRECQLHPGDTSHR | |
| SCHEMBL13367642 | 0.89 | MAPT (0.39) | ALDH1A1MAPTRECQLHPGDTSHR | |
| SCHEMBL13367651 | 0.88 | RXRA (0.43) | ALDH1A1MAPTRECQLHPGDTSHR | |
| SCHEMBL15786429 | 0.85 | REN (0.38) | ALDH1A1MAPTRECQLHPGDTSHR | |
| SCHEMBL16601579 | 0.85 | MAPT (0.38) | ALDH1A1MAPTRECQLHPGDTSHR | |
| SCHEMBL13960946 | 0.84 | ALDH1A1 (0.37) | ALDH1A1MAPTRECQLRENUSP2 | |
| SCHEMBL13340925 | 0.82 | OPRD1 (0.43) | ALDH1A1MAPTRECQLPOLBMEN1 | |
| SCHEMBL13367654 | 0.81 | NR3C2 (0.39) | ALDH1A1MAPTTSHRPOLBKMT2A | |
| SCHEMBL15161226 | 0.80 | PDE3B (0.49) | ALDH1A1MAPTHPGDTSHRNPSR1 | |
| SCHEMBL15786401 | 0.80 | MAPT (0.40) | ALDH1A1MAPTRECQLHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |