SCHEMBL16601772

SCHEMBL16601772

O=C1c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)C(=O)N1c1ccccc1CCO)c64)C(=O)N(c1ccccc1CCO)C5=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H3 Q13133 5/20 0.50
NR1H2 P55055 4/20 0.50
TERT O14746 3/20 0.43
MEN1 O00255 6/20 0.42
KMT2A Q03164 6/20 0.42
ALDH1A1 P00352 3/20 0.42
USP2 O75604 2/20 0.42
MAPT P10636 2/20 0.42
GAA P10253 2/20 0.42
CRHBP P24387 1/20 0.42
CASP1 P29466 1/20 0.42
BRCA1 P38398 1/20 0.42
CASP7 P55210 1/20 0.42
HBB P68871 1/20 0.42
CRHR2 Q13324 1/20 0.42
HSD17B10 Q99714 1/20 0.42
BRD1 O95696 2/20 0.38
TAF1 P21675 2/20 0.38
BRPF1 P55201 2/20 0.38
TAF1L Q8IZX4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601691 0.94 NR1H3 (0.55) NR1H3NR1H2MEN1KMT2AALDH1A1
SCHEMBL16601810 0.90 ANPEP (0.48) NR1H3NR1H2TERTMEN1KMT2A
SCHEMBL1904159 0.84 NR1H3 (0.68) NR1H3NR1H2ALDH1A1CASP1NPC1
SCHEMBL16601708 0.83 ANPEP (0.52) NR1H3NR1H2MEN1KMT2AALDH1A1
SCHEMBL16601813 0.82 NR1H3 (0.46) NR1H3NR1H2TERTMEN1KMT2A
SCHEMBL16417481 0.81 NR1H2 (0.50) NR1H3NR1H2MEN1KMT2AALDH1A1
SCHEMBL16601836 0.80 ALDH1A1 (0.54) TERTMEN1KMT2AALDH1A1USP2
SCHEMBL16601811 0.79 ANPEP (0.50) NR1H3NR1H2MEN1KMT2AALDH1A1
SCHEMBL16601826 0.79 POLB (0.43) NR1H3NR1H2MEN1KMT2AALDH1A1
SCHEMBL16601982 0.75 CA12 (0.49) NR1H3NR1H2TERTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed