SCHEMBL16601816

SCHEMBL16601816

CCCCCCN1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(c1c(C)cccc1CC)C3=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.46
RGS12 O14924 2/20 0.46
HTT P42858 2/20 0.46
KMT2A Q03164 2/20 0.46
USP2 O75604 1/20 0.46
POLB P06746 1/20 0.46
MAPT P10636 1/20 0.46
MAPK1 P28482 1/20 0.46
ATM Q13315 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
TLR9 Q9NR96 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
FGFR1 P11362 2/20 0.44
KDR P35968 2/20 0.44
PDGFRA P16234 1/20 0.44
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.43
NPC1 O15118 1/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601663 0.91 KDM4E (0.58) MEN1RGS12HTTKMT2AUSP2
SCHEMBL16601812 0.87 HTT (0.53) MEN1RGS12HTTKMT2AUSP2
SCHEMBL13045764 0.85 DPP4 (0.55) MEN1HTTKMT2APOLBMAPT
SCHEMBL12656452 0.83 DPP4 (0.50) MEN1RGS12HTTKMT2AUSP2
SCHEMBL16602024 0.82 DPP4 (0.50) MEN1RGS12HTTKMT2AUSP2
SCHEMBL16601693 0.82 TERT (0.45) MEN1RGS12HTTKMT2AUSP2
SCHEMBL12556882 0.82 DPP4 (0.42) MEN1HTTKMT2AMAPTMAPK1
SCHEMBL14181977 0.80 TOP2A (0.37) MEN1RGS12HTTKMT2AUSP2
SCHEMBL12132257 0.80 ALDH1A1 (0.65) MEN1RGS12HTTKMT2AUSP2
SCHEMBL7484669 0.80 ALDH1A1 (0.65) MEN1RGS12HTTKMT2AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9817326-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-11-14 US disclosed
EP-2680081-B1 Method for producing electrophotographic photosensitive member CANON KK (JP) 2016-08-10 EP disclosed
US-20160216622-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-07-28 US disclosed
US-20160054666-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2016-02-25 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed