Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920937 | 0.82 | PTGS2 (0.57) | ERN1LMNATUBB1PRKDCALDH1A1 | |
| SCHEMBL11851066 | 0.80 | ERN1 (0.50) | ERN1LMNAPRKDCALDH1A1TSHR | |
| SCHEMBL283354 | 0.77 | ERN1 (0.66) | ERN1LMNAPRKDCALDH1A1TSHR | |
| SCHEMBL22437205 | 0.76 | IGF1R (0.37) | ERN1TUBB1ALDH1A1MAPTHPGD | |
| SCHEMBL2240920 | 0.75 | ERN1 (0.63) | ERN1LMNAPRKDCALDH1A1TSHR | |
| SCHEMBL20658120 | 0.74 | PPARG (0.50) | LMNACA2PTGS2 | |
| SCHEMBL15451058 | 0.74 | ERN1 (0.41) | ERN1LMNATUBB1PRKDCALDH1A1 | |
| SCHEMBL439961 | 0.74 | ERN1 (0.52) | ERN1LMNAPRKDCALDH1A1TSHR | |
| SCHEMBL13362398 | 0.74 | ALDH1A1 (0.59) | ERN1LMNAPRKDCALDH1A1TSHR | |
| SCHEMBL415683 | 0.74 | ERN1 (0.57) | ERN1LMNAPRKDCALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007133-B | 3-phenylpyrazolo [5,1-b ] thiazole compounds | EISAI R&D MAN CO LTD | 2013-06-12 | — | — | CN | disclosed |
| US-8431603-B2 | 3-phenylpyrazolo[5,1-b]thiazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-30 | — | — | US | disclosed |
| US-8431603-B2 | 3-phenylpyrazolo[5,1-b]thiazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-30 | — | — | US | disclosed |
| US-8431603-B2 | 3-phenylpyrazolo[5,1-b]thiazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-30 | — | — | US | disclosed |
| EP-2266990-B1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-26 | — | — | EP | disclosed |
| EP-2487177-A1 | PYRAZOLOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-14 | — | — | US | disclosed |
| CN-102007133-A | 3-phenylpyrazolo [5,1-b ] thiazole compounds | EISAI R&D MAN CO LTD | 2011-04-06 | — | — | CN | disclosed |
| EP-2266990-A1 | 3-PHENYLPYRAZOLOÝ5,1-b¨THIAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009128383-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2009-10-22 | — | — | WO | disclosed |
| US-20090259049-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-10-15 | — | — | US | disclosed |
| US-20090259049-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-10-15 | — | — | US | disclosed |
| US-20090259049-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-10-15 | — | — | US | disclosed |
| US-3931181-A | BACTERICIDE | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | CRHR1, MC2R, CRHR2 | ERN1 2839/4885LMNA 4788/4885TUBB1 4345/4885 |
| US-20090259049-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS | CRHR1, AGTR1, CRHR2 | ERN1 1105/4885LMNA 4312/4885TUBB1 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.