Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479162 | 0.84 | HCRTR2 (0.39) | KMT2AHCRTR2MAPTHCRTR1HDAC1 | |
| SCHEMBL16612865 | 0.83 | HCRTR2 (0.38) | HCRTR2 | |
| SCHEMBL16612738 | 0.82 | HCRTR2 (0.36) | SYKHCRTR2 | |
| SCHEMBL16612726 | 0.81 | ALDH1A1 (0.40) | KDM4EHCRTR2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL16612742 | 0.78 | HCRTR2 (0.39) | HCRTR2HCRTR1HDAC1 | |
| SCHEMBL16612690 | 0.78 | HCRTR2 (0.35) | SYKHCRTR2 | |
| SCHEMBL16612825 | 0.76 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL16612872 | 0.75 | HCRTR2 (0.41) | SYKHCRTR2 | |
| SCHEMBL16612841 | 0.75 | MAPT (0.40) | KMT2AKDM4EMEN1HCRTR2MAPT | |
| SCHEMBL16612683 | 0.75 | FDPS (0.45) | SYKHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |