SCHEMBL16612880

SCHEMBL16612880

NC(=O)c1[c]cn(CCOc2ccc3c(c2)OCO3)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.45
DRD3 P35462 2/20 0.45
MAOB P27338 5/20 0.44
NPC1 O15118 5/20 0.43
RAB9A P51151 5/20 0.43
FKBP1A P62942 1/20 0.43
TSHR P16473 4/20 0.42
MAOA P21397 2/20 0.42
IDO1 P14902 1/20 0.41
MAPT P10636 3/20 0.40
MAPK1 P28482 2/20 0.40
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
HCRTR2 O43614 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16612775 0.78 MAOB (0.41) MAOBNPC1RAB9ATSHRHPGD
SCHEMBL16612857 0.76 MTNR1A (0.44) DRD2DRD3NPC1RAB9ATSHR
SCHEMBL16612828 0.76 SIRT2 (0.39) DRD2MAOBKMT2AHCRTR2SMN1; SMN2
SCHEMBL16613032 0.75 HCRTR2 (0.44) CYP1A2HCRTR2POLB
SCHEMBL12479530 0.70 MAOB (0.50) DRD2DRD3MAOBNPC1RAB9A
SCHEMBL16612990 0.70 HCRTR2 (0.39) HCRTR2ALDH1A1
SCHEMBL107322 0.69 MAOB (0.83) MAOBNPC1RAB9AFKBP1ATSHR
SCHEMBL28851447 0.69 FKBP1A (0.62) MAOBNPC1RAB9AFKBP1ATSHR
SCHEMBL16612712 0.68 HCRTR2 (0.38) CYP1A2CYP3A4TDP1HCRTR2POLB
SCHEMBL108114 0.68 MAOB (0.74) MAOBNPC1RAB9AFKBP1ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2675801-B1 NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2015-04-08 EP claimed