Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612828 | 0.85 | SIRT2 (0.39) | MAOBPARP10SMN1; SMN2 | |
| SCHEMBL16612857 | 0.78 | MTNR1A (0.44) | RAB9ANPC1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL15520768 | 0.77 | LMNA (0.40) | MAOBPARP10RAB9ANPC1TSHR | |
| SCHEMBL16612877 | 0.74 | HCRTR2 (0.35) | — | |
| SCHEMBL16612990 | 0.73 | HCRTR2 (0.39) | — | |
| SCHEMBL16612782 | 0.73 | HCRTR2 (0.39) | — | |
| SCHEMBL16612665 | 0.72 | HCRTR2 (0.39) | — | |
| SCHEMBL16612712 | 0.72 | HCRTR2 (0.38) | SMN1; SMN2 | |
| SCHEMBL16612643 | 0.72 | HCRTR1 (0.39) | — | |
| SCHEMBL16612923 | 0.71 | LTA4H (0.43) | RAB9ANPC1LTA4HHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |