Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612878 | 0.80 | KMT2A (0.46) | HTR2AHTR6HTR1AHTR2CHTR7 | |
| SCHEMBL16612961 | 0.78 | MTNR1A (0.53) | MTNR1AMTNR1BHTR6HCRTR2HTR1A | |
| SCHEMBL12479180 | 0.78 | MTNR1A (0.55) | HTR2AMTNR1AMTNR1BHTR6HTR1A | |
| SCHEMBL16612679 | 0.78 | HTR2A (0.52) | HTR2AMTNR1AMTNR1BHTR6HCRTR2 | |
| SCHEMBL16612788 | 0.74 | MPO (0.56) | HTR2AMTNR1AMTNR1BHTR1A | |
| SCHEMBL12479224 | 0.72 | HTR2A (0.58) | HTR2AMTNR1AMTNR1BSCN5ASCN2A | |
| SCHEMBL18509268 | 0.72 | MTNR1A (0.68) | HTR2AMTNR1AMTNR1BSCN5ASCN2A | |
| SCHEMBL16612943 | 0.71 | SIGMAR1 (0.47) | MTNR1AMTNR1B | |
| SCHEMBL16179253 | 0.70 | HTR2A (0.73) | HTR2AMTNR1AMTNR1BSCN5ASCN2A | |
| SCHEMBL1460696 | 0.70 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BSCN5ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |