Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479180 | 0.92 | MTNR1A (0.55) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL16612878 | 0.82 | KMT2A (0.46) | HTR2AMEN1KMT2AHTR6MAPT | |
| SCHEMBL16612770 | 0.81 | ADRB2 (0.44) | MEN1KMT2AMTNR1AMTNR1BHTR6 | |
| SCHEMBL16612796 | 0.79 | ADRB2 (0.55) | MEN1KMT2AMTNR1AMTNR1BHTR6 | |
| SCHEMBL16612788 | 0.78 | MPO (0.56) | HTR2AKMT2AMTNR1AMTNR1B | |
| SCHEMBL16612934 | 0.78 | HTR2A (0.52) | HTR2AMTNR1AMTNR1BHTR6HCRTR2 | |
| SCHEMBL16612961 | 0.78 | MTNR1A (0.53) | MEN1KMT2AMTNR1AMTNR1BHTR6 | |
| SCHEMBL16612943 | 0.76 | SIGMAR1 (0.47) | MTNR1AMTNR1B | |
| SCHEMBL8020879 | 0.73 | HTR2A (0.67) | HTR2AMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL16612680 | 0.72 | HTR2A (0.58) | HTR2AMEN1KMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |