Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9113694 | 0.86 | PTGS2 (0.38) | PTGS2NPC1MAPTRAB9ALMNA | |
| SCHEMBL9114912 | 0.75 | ACACA (0.41) | FFAR4 | |
| SCHEMBL9113017 | 0.74 | RXFP1 (0.41) | NPC1MAPTRAB9ALMNATP53 | |
| SCHEMBL9112880 | 0.70 | ACACB (0.46) | — | |
| SCHEMBL9112650 | 0.70 | PTGS2 (0.39) | PTGS2TP53HMOX1RXFP1 | |
| SCHEMBL9110377 | 0.70 | ACACA (0.45) | FFAR4 | |
| SCHEMBL9112061 | 0.69 | MTNR1A (0.50) | — | |
| SCHEMBL30131014 | 0.67 | NQO1 (0.41) | NPC1MAPTRAB9ALMNATP53 | |
| SCHEMBL9110148 | 0.66 | ACACB (0.41) | — | |
| SCHEMBL16622808 | 0.66 | PARP10 (0.39) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649062-B1 | BICYCLIC COMPOUNDS AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | TAKEDA PHARMACEUTICAL (JP) | 2015-04-08 | — | — | EP | disclosed |