Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SPR | P35270 | 2/20 | 0.54 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.53 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615787 | 0.84 | ALDH1A1 (0.81) | ALDH1A1MAPTMAPK1HSP90AA1NPSR1 | |
| SCHEMBL16615651 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTMAPK1HSP90AA1NPSR1 | |
| SCHEMBL17952790 | 0.81 | HPGD (0.57) | ALDH1A1MAPTMAPK1HSP90AA1NPSR1 | |
| SCHEMBL2852098 | 0.78 | GPR142 (0.52) | ALDH1A1MAPTMAPK1POLB | |
| SCHEMBL27405 | 0.78 | MAPK1 (0.78) | MAPTMAPK1HPGDNPC1RAB9A | |
| SCHEMBL2544046 | 0.76 | MAPK1 (1.00) | MAPTMAPK1HPGDNPC1RAB9A | |
| SCHEMBL2856089 | 0.76 | HPGD (1.00) | MAPK1HPGDNPC1RAB9AKMT2A | |
| SCHEMBL19902355 | 0.76 | MAPK1 (0.69) | ALDH1A1MAPTMAPK1HPGDNPC1 | |
| SCHEMBL16615748 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MAPTMAPK1HSP90AA1NPSR1 | |
| SCHEMBL3517559 | 0.75 | MAPK1 (0.73) | ALDH1A1MAPTMAPK1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10092574-B2 | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof | VALORISATION-RECHERCHE, LIMITED PARTNERSHIP (CA) | 2018-10-09 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| WO-2015042685-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | VALORISATION-RECHERCHE (CA) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10092574-B2 | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof | FBL, HNRNPA1, HNRNPUL1 | ALDH1A1 4383/4885MAPT 417/4885MAPK1 1991/4885 |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | FBL, HNRNPA1, HNRNPUL1 | ALDH1A1 4383/4885MAPT 417/4885MAPK1 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.