Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 10/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615837 | 0.76 | VNN1 (0.48) | VNN1GAACHRM3ROCK2ROCK1 | |
| SCHEMBL11627692 | 0.69 | VNN1 (0.67) | VNN1ROCK2ALDH1A1 | |
| SCHEMBL7985996 | 0.68 | GAA (0.56) | VNN1GAACHRM3ALDH1A1 | |
| SCHEMBL17142140 | 0.68 | HDAC2 (0.64) | VNN1GAAGPR139CHRM3ALDH1A1 | |
| SCHEMBL7986109 | 0.67 | MAOB (0.55) | VNN1GAACHRM3ALDH1A1 | |
| SCHEMBL7972494 | 0.67 | MAOB (0.55) | VNN1GAACHRM3ALDH1A1 | |
| SCHEMBL5091359 | 0.67 | CHRM3 (0.54) | VNN1GAAGPR139CHRM3ROCK2 | |
| SCHEMBL7233161 | 0.67 | CHRM3 (0.54) | VNN1GAAGPR139CHRM3ROCK2 | |
| SCHEMBL7983783 | 0.66 | MAOB (0.54) | VNN1GAACHRM3ALDH1A1 | |
| SCHEMBL5099622 | 0.66 | ROCK2 (0.62) | GAAGPR139CHRM3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048503-A2 | N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | disclosed |