Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619354 | 1.00 | SIRT5 (0.39) | SIRT5ALDH1A1HTTGAAMAPT | |
| SCHEMBL16619018 | 0.92 | MAPT (0.43) | ALDH1A1MAPTTP53CYP2C9CYP2C19 | |
| SCHEMBL16618796 | 0.91 | ALDH1A1 (0.40) | ALDH1A1HTTGAAMAPTNPSR1 | |
| SCHEMBL16618793 | 0.91 | ALDH1A1 (0.40) | ALDH1A1HTTGAAMAPTNPSR1 | |
| SCHEMBL16619487 | 0.87 | EGFR (0.39) | PLK1KDM4E | |
| SCHEMBL16619317 | 0.86 | EGFR (0.38) | ALDH1A1HTTGAACRHBPCRHR2 | |
| SCHEMBL16619320 | 0.86 | EGFR (0.38) | ALDH1A1HTTGAACRHBPCRHR2 | |
| SCHEMBL16619418 | 0.84 | KDM4E (0.46) | ALDH1A1HTTGAAMAPTNPSR1 | |
| SCHEMBL16619416 | 0.84 | KDM4E (0.46) | ALDH1A1HTTGAAMAPTNPSR1 | |
| SCHEMBL16619219 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HTTGAAMAPTCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049629-A1 | IMIDAZOQUINOLINE COMPOUNDS AS BROMODOMAIN INHIBITORS | Piramal Enterprises Limited (IN) | 2015-04-09 | — | — | WO | disclosed |