Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GLP1R | P43220 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17986539 | 1.00 | CETP (0.33) | CETPMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16630633 | 1.00 | CETP (0.33) | CETPMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16629886 | 0.91 | GPR119 (0.35) | CETPMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16629887 | 0.83 | GPR119 (0.37) | CETPMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL18017450 | 0.82 | GPR119 (0.36) | CETPMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16629834 | 0.81 | AGTR2 (0.36) | CETPKMT2A | |
| SCHEMBL17986568 | 0.81 | CETP (0.32) | CETPMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL18017379 | 0.80 | ADRB1 (0.38) | CETPMEN1KMT2A | |
| SCHEMBL16620038 | 0.80 | ADRB1 (0.38) | CETPMEN1KMT2A | |
| SCHEMBL16620041 | 0.80 | ADRB1 (0.38) | CETPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052099-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | Merck Sharp & Dohme Corp. (US) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015050798-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-04-09 | — | — | WO | disclosed |