Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | CETP | P11597 | 5/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 2/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17986572 | 0.89 | GPR119 (0.35) | GPR119ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17986573 | 0.89 | GPR119 (0.35) | GPR119ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL16619731 | 0.89 | GPR119 (0.35) | GPR119ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL16629834 | 0.85 | AGTR2 (0.36) | GPR119KMT2ACETP | |
| SCHEMBL16630588 | 0.84 | ACACB (0.40) | GPR119MEN1KMT2AOPRD1KCNH2 | |
| SCHEMBL17986539 | 0.83 | CETP (0.33) | ALDH1A1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL16630633 | 0.83 | CETP (0.33) | ALDH1A1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL16620264 | 0.83 | CETP (0.33) | ALDH1A1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL18017379 | 0.83 | ADRB1 (0.38) | GPR119MEN1KMT2ACETPHPGD | |
| SCHEMBL16620038 | 0.83 | ADRB1 (0.38) | GPR119MEN1KMT2ACETPHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050798-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-04-09 | — | — | WO | disclosed |