SCHEMBL1662279

SCHEMBL1662279

N#Cc1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+](=O)[O-]

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 9/20 1.00
GRIA1 P42261 8/20 1.00
GRIA3 P42263 8/20 1.00
GRIA4 P48058 8/20 1.00
MAPT P10636 3/20 1.00
CYP1A2 P05177 2/20 1.00
ALOX15 P16050 1/20 1.00
GRIN2D O15399 4/20 0.67
GRIN3B O60391 4/20 0.67
GRIN1 Q05586 4/20 0.67
GRIN2A Q12879 4/20 0.67
GRIN2B Q13224 4/20 0.67
GRIN2C Q14957 4/20 0.67
GRIN3A Q8TCU5 4/20 0.67
GRIK1 P39086 2/20 0.67
GRIK2 Q13002 2/20 0.67
GRIK3 Q13003 2/20 0.67
GRIK4 Q16099 2/20 0.67
GRIK5 Q16478 2/20 0.67
HPGD P15428 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30905563 1.00 GRIA2 (1.00) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL3686717 0.83 GRIA2 (0.71) GRIA2GRIA1GRIA3GRIA4MAPT
Dnqx SCHEMBL594575 0.81 GRIA2 (1.00) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL9971326 0.79 GRIA1 (0.63) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL9393185 0.78 GRIA1 (0.63) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL12619187 0.78 GRIA1 (0.63) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL25389388 0.76 MAPT (0.61) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL7417792 0.74 GRIA1 (0.56) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL9746827 0.73 GRIA1 (0.63) GRIA2GRIA1GRIA3GRIA4MAPT
SCHEMBL7482757 0.73 GRIA2 (0.74) GRIA2GRIA1GRIA3GRIA4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025065271-A1 METHODS AND DEVICES FOR TREATING DEPRESSION Liangzhu Laboratory (CN) 2025-04-03 WO claimed
WO-2023196234-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-12 WO claimed
US-20230310380-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-05 US claimed
US-20220251627-A1 COMPOSITIONS FOR THE STABILIZATION OF CELL-FREE NUCLEIC ACIDS AND METHODS THEREOF ZYMO RESEARCH CORPORATION (US) 2022-08-11 US claimed
EP-3989722-A1 COMPOSITIONS FOR THE STABILIZATION OF CELL-FREE NUCLEIC ACIDS AND METHODS THEREOF Zymo Research Corporation (US) 2022-05-04 EP claimed
WO-2026101998-A1 THREE-DIMENSIONAL MICROINSTRUMENTED NEURAL NETWORK DEVICE THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2026-05-15 WO disclosed
US-12616807-B2 Medical counter measures including dry powder formulations and associated methods Belhaven BioPharma Inc. (US) 2026-05-05 US disclosed
US-12600985-B2 Compositions and methods for controlling production of polypeptides in cells THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-04-14 US disclosed
US-12576042-B2 Methods and compositions for treating neurological conditions LIPTON STUART A (US) 2026-03-17 US disclosed
US-12515077-B2 Devices and methods based on ultrasounds for restoring vision or any other brain function SORBONNE UNIVERSITE (GR) 2026-01-06 US disclosed
US-20250345365-A1 TREATMENT OF NEURONAL DISEASES CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECH CHINESE ACADEMY OF SCIENCES (CN) 2025-11-13 US disclosed
US-20250340884-A1 ANTISENSE OLIGOMERS AGAINST MONOAMINE OXIDASE B AND USE THEREOF INST BASIC SCIENCE (KR) 2025-11-06 US disclosed
US-6147075-A ANALGESICS; PSYCHOLOGICAL DISORDERS COCENSYS, INC. (US) 2000-11-14 US disclosed
WO-2000054772-A1 AMYOTROPIC LATERAL SCLEROSIS TREATMENT WITH A COMBINATION OF RILUZOLE AND AN AMPA RECEPTOR ANTAGONIST AVENTIS PHARMA S.A. (FR) 2000-09-21 WO disclosed
US-5977107-A Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonists COCENSYS, INC. (US) 1999-11-02 US disclosed
US-5631373-A NERVOUS SYSTEM DISORDERS STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-05-20 US disclosed
US-5622952-A NERVOUS SYSTEM DISORDERS; ADMINISTERING 1,4-DIHYDROQUINOXALINE-2,3-DIONE STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-04-22 US disclosed
US-5620979-A TREATING NEURONAL LOSS ASSOCIATED WITH STROKE, ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA OR SURGERY STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-04-15 US disclosed
US-5514680-A ANTICONVULSANTS WITH 5,6,7-TRISUBSTITUTED-1,4-DIHYDROQUINOXALINE-2,3-DIONE THE STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) 1996-05-07 US disclosed
WO-1994000124-A1 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF WEBER ECKARD (US) 1994-01-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12616807-B2 Medical counter measures including dry powder formulations and associated methods ADRB2, ADRB3, MC5R GRIA2 1365/4885GRIA1 1312/4885GRIA3 1422/4885
US-12600985-B2 Compositions and methods for controlling production of polypeptides in cells FOSB, CALCB, CHERP GRIA2 595/4885GRIA1 1173/4885GRIA3 759/4885
US-12576042-B2 Methods and compositions for treating neurological conditions NCSTN, GRIN2C, NOTCH1 GRIA2 160/4885GRIA1 356/4885GRIA3 108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.