Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849240 | 0.88 | JAK1 (0.43) | JAK1JAK2EPHX1MEN1RAB9A | |
| SCHEMBL20246042 | 0.87 | RAB9A (0.46) | JAK1JAK2EPHX1MEN1NPC1 | |
| SCHEMBL16623571 | 0.86 | JAK1 (0.34) | JAK1JAK2EPHX1MEN1NPC1 | |
| SCHEMBL20246056 | 0.85 | HCAR3 (0.40) | JAK1JAK2EPHX1MEN1NPC1 | |
| SCHEMBL20246309 | 0.85 | EPHX1 (0.47) | JAK1JAK2EPHX1NPC1RAB9A | |
| SCHEMBL16623464 | 0.84 | JAK1 (0.38) | JAK1JAK2 | |
| SCHEMBL20246179 | 0.84 | BRD4 (0.44) | JAK1JAK2KMT2A | |
| SCHEMBL20246553 | 0.84 | JAK1 (0.37) | JAK1JAK2IP6K1EPHX1MEN1 | |
| SCHEMBL20246326 | 0.84 | LMNA (0.46) | JAK1JAK2EPHX1MEN1KMT2A | |
| SCHEMBL16623542 | 0.83 | JAK1 (0.39) | JAK1JAK2IP6K1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |