Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21891645 | 0.83 | TSHR (0.35) | TSHR | |
| SCHEMBL16623949 | 0.82 | TSHR (0.39) | TSHRALDH1A1ALOX15 | |
| SCHEMBL16623950 | 0.78 | TSHR (0.39) | TSHRALDH1A1 | |
| SCHEMBL12332936 | 0.71 | TSHR (0.37) | TSHRALDH1A1 | |
| SCHEMBL8389036 | 0.70 | TSHR (0.41) | TSHRHPGDALDH1A1 | |
| SCHEMBL1252570 | 0.70 | TSHR (0.55) | TSHRHPGDALDH1A1 | |
| SCHEMBL8389037 | 0.69 | TSHR (0.41) | TSHRHPGD | |
| Iodide SCHEMBL1254864 | 0.69 | TSHR (0.53) | TSHRHPGDALDH1A1 | |
| Fluoride SCHEMBL1254145 | 0.69 | TSHR (0.53) | TSHRHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL1252915 | 0.69 | TSHR (0.53) | TSHRHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10780026-B2 | Methods of forming dental composites and compositions for reduced shrinkage stress | DENTSPLY SIRONA INC. (US) | 2020-09-22 | — | — | US | disclosed |
| EP-3052481-B1 | USE OF POLYMERIZABLE STABLE RADICALS FOR REDUCING THE SHRINKAGE STRESS OF DENTAL COMPOSITIONS | DENTSPLY SIRONA INC (US) | 2020-04-08 | — | — | EP | disclosed |
| US-20190224081-A1 | METHODS OF FORMING DENTAL COMPOSITES AND COMPOSITIONS FOR REDUCED SHRINKAGE STRESS | DENTSPLY SIRONA INC (US) | 2019-07-25 | — | — | US | disclosed |
| US-9931280-B2 | Dental composite compositions for reduced shrinkage stress | DENTSPLY SIRONA INC. (US) | 2018-04-03 | — | — | US | disclosed |
| WO-2015051217-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | DENTSPLY INTERNATIONAL INC. (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | DENTSPLY SIRONA INC. | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | VCL, HSPA4L, GPX4 | TSHR 3714/4885HPGD 419/4885ALDH1A1 2471/4885 |
| US-10780026-B2 | Methods of forming dental composites and compositions for reduced shrinkage stress | SMCHD1, FHIT, ACR | TSHR 2671/4885HPGD 320/4885ALDH1A1 1551/4885 |
| US-20190224081-A1 | METHODS OF FORMING DENTAL COMPOSITES AND COMPOSITIONS FOR REDUCED SHRINKAGE STRESS | SMCHD1, FHIT, ACR | TSHR 2671/4885HPGD 320/4885ALDH1A1 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.