Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18034945 | 0.85 | CYP2D6 (0.62) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL17993835 | 0.82 | KDM4E (0.46) | KDM4EACHETRPV1BAZ2BCDK4 | |
| SCHEMBL17993840 | 0.82 | HTR7 (0.55) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL17993837 | 0.81 | ADRA1A (0.45) | KDM4EMEN1KMT2AADRA1ATRPV1 | |
| SCHEMBL29564708 | 0.81 | CYP2D6 (0.64) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL25192385 | 0.81 | CYP2D6 (0.64) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL18033535 | 0.81 | KDM4E (0.44) | KDM4EMEN1KMT2AMAPTTRPV1 | |
| SCHEMBL16624295 | 0.81 | MEN1 (0.45) | KDM4EMEN1KMT2AGAAMAPT | |
| SCHEMBL25183522 | 0.77 | HTR7 (0.56) | HTR7ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL16624095 | 0.77 | KIF11 (0.46) | KDM4EALDH1A1MAPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3053917-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nissan Chemical Industries, Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015050212-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日産化学工業株式会社 | 2015-04-09 | — | — | WO | disclosed |