SCHEMBL16626728

SCHEMBL16626728

CNCc1cn(S(=O)(=O)c2cccnc2)c2cc(Nc3ccc(OC)nc3Cl)ccc12

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.37
HTR6 P50406 8/20 0.35
IDE P14735 1/20 0.35
TSHR P16473 1/20 0.34
MTNR1A P48039 1/20 0.33
MTNR1B P49286 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
FGFR4 P22455 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
PIK3CG P48736 3/20 0.32
KEAP1 Q14145 1/20 0.32
NFE2L2 Q16236 1/20 0.32
NAMPT P43490 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16619198 0.99 FBP1 (0.37) FBP1HTR6IDETSHRMTNR1A
SCHEMBL16626699 0.91 HTR6 (0.35) FBP1HTR6IDETSHRMTNR1A
Hydrochloric Acid SCHEMBL16618944 0.91 HTR6 (0.35) FBP1HTR6IDETSHRMTNR1A
SCHEMBL16626483 0.90 IDE (0.36) FBP1HTR6IDETSHRPDE4A
Hydrochloric Acid SCHEMBL16618546 0.90 IDE (0.36) FBP1HTR6IDETSHRPDE4A
SCHEMBL16626479 0.90 IDE (0.36) FBP1HTR6IDETSHRPDE4A
Hydrochloric Acid SCHEMBL16618712 0.89 IDE (0.36) FBP1HTR6IDETSHRPDE4A
SCHEMBL16626513 0.89 HTR6 (0.42) HTR6MTNR1AMTNR1B
SCHEMBL16626735 0.88 HTR6 (0.34) HTR6MTNR1AMTNR1BPDE4APDE4B
Hydrochloric Acid SCHEMBL16619127 0.88 HTR6 (0.42) HTR6MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP claimed
US-9676714-B2 Sulfonylindole derivatives and method for preparing the same DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2017-06-13 US disclosed
US-20160221946-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2016-08-04 US disclosed
WO-2015050412-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2015-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160221946-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME GIPR, PGC, SI FBP1 74/4885HTR6 166/4885IDE 2586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.