Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623995 | 0.73 | THRB (0.38) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL9008779 | 0.70 | THRB (0.42) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL1337099 | 0.69 | THRB (0.57) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL844386 | 0.68 | THRB (0.55) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL2721270 | 0.68 | THRB (0.55) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL13567318 | 0.68 | THRB (0.40) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL7510697 | 0.67 | GAA (0.44) | TSHRALDH1A1 | |
| SCHEMBL6142874 | 0.67 | THRB (0.74) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL15636 | 0.67 | THRB (0.74) | THRBTSHRCA1CA2ALDH1A1 | |
| SCHEMBL20956850 | 0.67 | THRB (0.53) | THRBTSHRCA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9931280-B2 | Dental composite compositions for reduced shrinkage stress | DENTSPLY SIRONA INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | DENTSPLY SIRONA INC. | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | VCL, HSPA4L, GPX4 | THRB 2570/4885TSHR 3714/4885CA1 3578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.