Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16624737 | 0.89 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBABCG2LMNAALDH1A1 | |
| SCHEMBL16627093 | 0.87 | MEN1 (0.43) | SMN1; SMN2ABCG2LMNAALDH1A1KMT2A | |
| SCHEMBL16624740 | 0.82 | ALDH1A1 (0.49) | SMN1; SMN2POLBLMNAALDH1A1KMT2A | |
| SCHEMBL16627091 | 0.81 | CYP1A2 (0.49) | SMN1; SMN2ABCG2ABCB1LMNAALDH1A1 | |
| SCHEMBL29488289 | 0.77 | ESR1 (0.56) | SMN1; SMN2POLBABCG2ABCB1BIRC5 | |
| SCHEMBL602028 | 0.77 | ESR1 (0.56) | SMN1; SMN2POLBABCG2ABCB1BIRC5 | |
| SCHEMBL16627090 | 0.72 | CYP1A2 (0.45) | SMN1; SMN2ABCG2ABCB1LMNAALDH1A1 | |
| SCHEMBL16624738 | 0.72 | L3MBTL1 (0.48) | SMN1; SMN2POLBLMNAALDH1A1KMT2A | |
| SCHEMBL16624714 | 0.71 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL25382436 | 0.71 | ABCG2 (0.55) | SMN1; SMN2POLBABCG2ABCB1BIRC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051044-A2 | NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE | NOVARTIS AG (CH) | 2015-04-09 | — | — | WO | disclosed |