SCHEMBL16627741

SCHEMBL16627741

CCn1c(=O)c(C(=O)Nc2ccccc2)cc2ccccc21

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.61
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
ALDH1A1 P00352 1/20 0.53
TSHR P16473 1/20 0.53
HTT P42858 1/20 0.53
CNR1 P21554 6/20 0.52
CNR2 P34972 6/20 0.51
RAB9A P51151 1/20 0.50
TP53 P04637 1/20 0.50
MAPT P10636 1/20 0.50
KDM1A O60341 1/20 0.49
RCOR1 Q9UKL0 1/20 0.49
F12 P00748 1/20 0.49
MAOA P21397 1/20 0.49
MAOB P27338 1/20 0.49
PDE10A Q9Y233 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16627748 0.92 AHR (0.73) AHRMEN1KMT2AALDH1A1TSHR
SCHEMBL16627757 0.91 AHR (0.72) AHRMEN1KMT2ACNR1CNR2
SCHEMBL16627762 0.89 AHR (0.56) AHRMEN1KMT2AALDH1A1TSHR
SCHEMBL30237030 0.83 AHR (0.85) AHRMEN1KMT2AALDH1A1TSHR
SCHEMBL1397253 0.83 AHR (0.85) AHRMEN1KMT2AALDH1A1TSHR
SCHEMBL16627568 0.83 CA12 (0.51) ALDH1A1CNR1CNR2
SCHEMBL16627808 0.81 AHR (0.61) AHRMEN1KMT2AALDH1A1TSHR
SCHEMBL6547150 0.80 MAPK1 (0.47) KMT2AALDH1A1CNR1CNR2
SCHEMBL16627765 0.77 MAPK1 (0.47) ALDH1A1CNR1CNR2TP53MAPT
SCHEMBL16627668 0.77 AHR (0.77) AHRMEN1KMT2AALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015050379-A1 NOVEL QUINOLINONE DERIVATIVE AND USE THEREOF 광주과학기술원 2015-04-09 WO disclosed