SCHEMBL16627909

SCHEMBL16627909

Oc1ccc(-c2cc[nH]n2)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 6/20 0.47
ESR1 P03372 5/20 0.43
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HSD17B1 P14061 4/20 0.40
HSD17B2 P37059 4/20 0.40
RIPK1 Q13546 1/20 0.40
CDK2 P24941 1/20 0.39
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
ADORA2A P29274 2/20 0.37
ADORA1 P30542 1/20 0.37
ERCC1 P07992 1/20 0.36
ERCC4 Q92889 1/20 0.36
HDAC2 Q92769 1/20 0.36
AR P10275 1/20 0.36
PTGS2 P35354 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1924473 0.83 APP (0.50) ESR2TSHRHSD17B10
SCHEMBL1829344 0.83 AHR (0.50)
SCHEMBL27916599 0.79 HDAC3 (0.43) ESR2ESR1TSHRCDK2GSK3A
SCHEMBL6787087 0.79 ALDH1A1 (0.46) TSHRPTGS2
SCHEMBL10200379 0.79 APP (0.34) ESR2
SCHEMBL6622908 0.77 XDH (0.52) TSHR
SCHEMBL8195799 0.76 KMO (0.49) TSHRADORA2AADORA1PTGS2
SCHEMBL22873416 0.75 HAO1 (0.31)
SCHEMBL1810795 0.75 CYP11B2 (0.48) AR
SCHEMBL13675152 0.75 HSD17B1 (0.47) ESR2ESR1HSD17B1HSD17B2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015050040-A1 PLANT DISEASE CONTROL COMPOSITION AND USE THEREOF 住友化学株式会社 2015-04-09 WO disclosed