Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 15/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
| ▸ | PDE6G | P18545 | 1/20 | 0.41 |
| ▸ | PDE6B | P35913 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19997558 | 0.84 | LMNA (0.53) | CHRM1PDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16628263 | 0.83 | POLB (0.56) | CHRM1POLBRPS6KB1GRM2 | |
| SCHEMBL16628328 | 0.83 | RPS6KB1 (0.54) | CHRM1POLBPARP1RPS6KB1GRM2 | |
| SCHEMBL18011014 | 0.83 | CHRM1 (0.43) | CHRM1PARP1PDE6DPDE6APDE6G | |
| SCHEMBL16628259 | 0.82 | ADRA1D (0.50) | CHRM1 | |
| SCHEMBL16628260 | 0.81 | CHRM1 (0.46) | CHRM1PDE6DPDE6APDE6GPDE6B | |
| SCHEMBL22001753 | 0.81 | POLB (0.53) | CHRM1POLBRPS6KB1GRM2 | |
| SCHEMBL19997523 | 0.80 | CHRM1 (0.48) | CHRM1PARP1PDE6DPDE6APDE6G | |
| SCHEMBL16593320 | 0.80 | CHRM1 (0.73) | CHRM1 | |
| SCHEMBL16628334 | 0.80 | NPC1 (0.44) | CHRM1POLBPARP1PDE6DPDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |