SCHEMBL16628419 — predicted protein targets

Known targets — ChEMBL curated mechanism

GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B HMGCR MMP1 MMP13 MMP7 MMP8 PTGS1 PTGS2 ileS pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	MMP1 known ✓	P03956	1/20	0.36

▸	CA12	O43570	2/20	0.48

▸	CA1	P00915	2/20	0.48

▸	CA2	P00918	2/20	0.48

▸	CA9	Q16790	2/20	0.48

▸	MMP2	P08253	1/20	0.36

▸	MMP3	P08254	1/20	0.36

▸	ALDH1A1	P00352	2/20	0.34

▸	KDM4E	B2RXH2	1/20	0.34

▸	KDM4C	Q9H3R0	1/20	0.34

▸	SMN1; SMN2	Q16637	2/20	0.33

▸	PKM	P14618	2/20	0.33

▸	STAT3	P40763	1/20	0.32

▸	HTT	P42858	2/20	0.31

▸	ALPL	P05186	1/20	0.31

▸	GAA	P10253	1/20	0.31

▸	L3MBTL1	Q9Y468	1/20	0.31

▸	EPHX1	P07099	1/20	0.31

▸	MEN1	O00255	1/20	0.31

▸	KMT2A	Q03164	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3898868	0.96	CA12 (0.48)	CA12CA1CA2CA9MMP1
Zinc Ion SCHEMBL10339254	0.96	CA12 (0.48)	CA12CA1CA2CA9MMP1
SCHEMBL16628523	0.96	CA12 (0.48)	CA12CA1CA2CA9MMP1
SCHEMBL16628418	0.83	POLB (0.38)	CA12CA1CA2CA9ALDH1A1
SCHEMBL16628445	0.82	CA12 (0.35)	CA12CA1CA2CA9MMP1
SCHEMBL3895942	0.79	POLB (0.38)	CA12CA1CA2CA9ALDH1A1
SCHEMBL16628522	0.79	POLB (0.38)	CA12CA1CA2CA9ALDH1A1
Zinc Ion SCHEMBL8355476	0.77	CA12 (0.35)	CA12CA1CA2CA9MMP1
SCHEMBL16628413	0.77	CA12 (0.35)	CA12CA1CA2CA9MMP1
SCHEMBL4614526	0.77	CA12 (0.35)	CA12CA1CA2CA9MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2860170-B1	PROCESS FOR PREPARING 4-HYDROXYBUTYL ACRYLATE	OSAKA ORGANIC CHEMICAL IND LTD (JP)	2019-08-28	—	—	EP	disclosed
US-9670129-B2	Process for preparing 4-hydroxybutyl acrylate	OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP)	2017-06-06	—	—	US	disclosed
US-20150126766-A1	PROCESS FOR PREPARING 4-HYDROXYBUTYL ACRYLATE	OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP)	2015-05-07	—	—	US	disclosed
EP-2860170-A1	PROCESS FOR PREPARING 4-HYDROXYBUTYL ACRYLATE	Osaka Organic Chemical Ind., Ltd. (JP)	2015-04-15	—	—	EP	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20150126766-A1	PROCESS FOR PREPARING 4-HYDROXYBUTYL ACRYLATE	LTB4R2, LTA4H, LTB4R	MMP1 4764/4885CA12 4614/4885CA1 4540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.