Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663062 | 0.84 | MTNR1A (0.44) | MTNR1AITGB3ITGA2BAPEX1HRH3 | |
| SCHEMBL1663128 | 0.82 | MTNR1A (0.56) | MTNR1AITGB3ITGA2BAPEX1HRH3 | |
| SCHEMBL1663735 | 0.80 | HRH3 (0.44) | MTNR1AITGB3ITGA2BAPEX1HRH3 | |
| SCHEMBL1663712 | 0.80 | MTNR1A (0.48) | MTNR1AITGB3ITGA2BHRH3KDM4E | |
| SCHEMBL8181089 | 0.76 | HRH3 (0.48) | APEX1HRH3KDM4ESMN1; SMN2 | |
| SCHEMBL13369810 | 0.75 | HRH3 (0.47) | MTNR1AAPEX1HRH3KDM4EMTNR1B | |
| SCHEMBL6152137 | 0.75 | HRH3 (0.53) | MTNR1AAPEX1HRH3KDM4EMTNR1B | |
| SCHEMBL13369823 | 0.74 | MTNR1A (0.51) | MTNR1AITGB3ITGA2BAPEX1HRH3 | |
| SCHEMBL1663077 | 0.74 | ALDH1A1 (0.54) | HRH3SMN1; SMN2APPHDAC1HDAC2 | |
| SCHEMBL4079956 | 0.73 | MTNR1A (0.42) | MTNR1AITGB3ITGA2BKDM4EMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |