Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663062 | 0.75 | MTNR1A (0.44) | MTNR1AKDM4EITGB3ITGA2BALDH1A1 | |
| SCHEMBL1663712 | 0.74 | MTNR1A (0.48) | MTNR1AKDM4EITGB3ITGA2BALDH1A1 | |
| SCHEMBL4076192 | 0.73 | KDM4E (0.45) | KDM4EPOLBPKMGFERALDH1A1 | |
| SCHEMBL1663190 | 0.73 | MTNR1A (0.40) | MTNR1AKDM4EITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL1663128 | 0.73 | MTNR1A (0.56) | MTNR1AKDM4EITGB3ITGA2BALDH1A1 | |
| SCHEMBL13369810 | 0.72 | HRH3 (0.47) | MTNR1AKDM4EALDH1A1PRMT1MTNR1B | |
| SCHEMBL1663735 | 0.72 | HRH3 (0.44) | MTNR1AKDM4EPOLBPKMITGB3 | |
| SCHEMBL6152137 | 0.70 | HRH3 (0.53) | MTNR1AKDM4EALDH1A1MTNR1B | |
| SCHEMBL14117470 | 0.70 | MTNR1A (0.48) | MTNR1AKDM4EPRMT1MTNR1BSIRT1 | |
| SCHEMBL4075137 | 0.69 | MEN1 (0.43) | MTNR1AKDM4EPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155362-A1 | SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |