Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281014 | 0.77 | PTGDR2 (0.48) | PTGDR2KDM4EPOLBCYP1A2MAPT | |
| SCHEMBL28053564 | 0.67 | PTGDR2 (0.34) | PTGDR2KDM4EPOLBCYP1A2MAPT | |
| SCHEMBL1664739 | 0.66 | ADORA1 (0.38) | KDM4EPOLBMAPTGAASMN1; SMN2 | |
| SCHEMBL851867 | 0.65 | SMN1; SMN2 (0.51) | PTGDR2KDM4EPOLBMAPTGAA | |
| SCHEMBL19287156 | 0.65 | GAA (0.55) | PTGDR2KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL3995474 | 0.60 | CKS1B (0.45) | KMT2ATP53MEN1LMNATDP1 | |
| SCHEMBL3993059 | 0.60 | S1PR3 (0.50) | KDM4EHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL2544178 | 0.59 | PTPN1 (0.47) | — | |
| SCHEMBL5746080 | 0.59 | MAPT (0.49) | KDM4ECYP1A2MAPTGAASMN1; SMN2 | |
| SCHEMBL5147356 | 0.59 | BCAT2 (0.43) | PTGDR2ALDH1A1KMT2ATP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490541-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. Lundbeck A/S (DK) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050063-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-04-28 | — | — | WO | disclosed |