Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637329 | 0.77 | OPRM1 (0.41) | L3MBTL1OPRM1OPRL1GAASMN1; SMN2 | |
| SCHEMBL1004649 | 0.64 | ALDH1A1 (0.73) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9595456 | 0.64 | KMT2A (0.66) | GAASMN1; SMN2RAB9AHPGDALDH1A1 | |
| SCHEMBL9431536 | 0.62 | SMN1; SMN2 (0.55) | L3MBTL1GAASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL5639628 | 0.61 | OPRM1 (0.39) | L3MBTL1OPRM1OPRL1GAASMN1; SMN2 | |
| SCHEMBL487487 | 0.61 | HPGD (0.61) | SMN1; SMN2HPGDALDH1A1MAPT | |
| SCHEMBL15387038 | 0.61 | HPGD (0.52) | GAASMN1; SMN2HPGDALDH1A1CYP1A2 | |
| SCHEMBL28513427 | 0.60 | GAA (0.47) | L3MBTL1GAASMN1; SMN2RAB9AHPGD | |
| SCHEMBL10405466 | 0.60 | ALDH1A1 (0.63) | L3MBTL1SMN1; SMN2RAB9AHPGDALDH1A1 | |
| SCHEMBL31702358 | 0.59 | GFER (0.43) | OPRM1OPRL1GAASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051713-A1 | 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRIDIN-2-ONE SPIRO DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 | 2015-04-16 | — | — | WO | disclosed |
| WO-2015051713-A1 | 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRIDIN-2-ONE SPIRO DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 | 2015-04-16 | — | — | WO | disclosed |