SCHEMBL16637276

SCHEMBL16637276

COCc1cnc(Cl)cc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.39
LMNA P02545 1/20 0.37
CACNA1H O95180 1/20 0.35
PIK3R1 P27986 1/20 0.35
PIK3CA P42336 1/20 0.35
CYP1A2 P05177 2/20 0.33
IDO1 P14902 4/20 0.33
MAPT P10636 1/20 0.32
AKR1C3 P42330 1/20 0.32
AKR1C2 P52895 1/20 0.32
HTT P42858 1/20 0.32
PDE10A Q9Y233 1/20 0.32
RXRA P19793 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16647331 0.83 LMNA (0.42) TRPA1LMNACACNA1HCYP1A2IDO1
SCHEMBL20457490 0.81 AKR1C3 (0.39) TRPA1PIK3R1PIK3CAAKR1C3AKR1C2
SCHEMBL25225499 0.80 DDR1 (0.38) LMNAPIK3R1PIK3CAAKR1C3AKR1C2
SCHEMBL29537108 0.80 DDR1 (0.38) LMNAPIK3R1PIK3CAAKR1C3AKR1C2
SCHEMBL16637809 0.77 PDXK (0.38) PIK3R1PIK3CAMAPTAKR1C3AKR1C2
SCHEMBL29091802 0.77 AKR1C3 (0.34) LMNAPIK3R1PIK3CAMAPTAKR1C3
SCHEMBL14989204 0.77 LMNA (0.42) LMNAMAPTHTTTDP1
SCHEMBL30877876 0.77 LMNA (0.42) LMNAMAPTHTTTDP1
SCHEMBL20489645 0.74 LMNA (0.36) LMNAMAPTTDP1
SCHEMBL28074115 0.74 HTR2A (0.40) TRPA1LMNAPIK3R1PIK3CACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11608323-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2023-03-21 US disclosed
EP-3054773-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2022-01-26 EP disclosed
EP-3054773-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2022-01-26 EP disclosed
CN-111961033-A Herbicidal compounds 先正达参股股份有限公司 2020-11-20 CN disclosed
US-20190112288-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-04-18 US disclosed
US-20190112288-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-04-18 US disclosed
EP-3060558-B1 PYRIDINYLIMIDAZOLONES AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-09-12 EP disclosed
US-20160264547-A1 Herbicidal Compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-09-15 US disclosed
US-20160264547-A1 Herbicidal Compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-09-15 US disclosed
US-20160264547-A1 Herbicidal Compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-09-15 US disclosed
US-20160251332-A1 Herbicidal Compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-09-01 US disclosed
US-20160251332-A1 Herbicidal Compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-09-01 US disclosed
US-20160251332-A1 Herbicidal Compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-09-01 US disclosed
EP-3060558-A1 PYRIDINYLIMIDAZOLONES AS HERBICIDES Syngenta Participations AG (CH) 2016-08-31 EP disclosed
EP-3054773-A1 HERBICIDAL COMPOUNDS Syngenta Participations AG (CH) 2016-08-17 EP disclosed
WO-2015059262-A1 PYRIDINYLIMIDAZOLONES AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2015-04-30 WO disclosed
WO-2015059262-A1 PYRIDINYLIMIDAZOLONES AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2015-04-30 WO disclosed
WO-2015052076-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190112288-A1 HERBICIDAL COMPOUNDS DDT, RDX, CBR3 TRPA1 3759/4885LMNA 4247/4885CACNA1H 4545/4885
US-20160251332-A1 Herbicidal Compounds RDX, CBR3, DDT TRPA1 3120/4885LMNA 3791/4885CACNA1H 3949/4885
US-20160264547-A1 Herbicidal Compounds DDT, RDX, CBR3 TRPA1 3677/4885LMNA 4223/4885CACNA1H 4543/4885
US-11608323-B2 Herbicidal compounds DDT, RDX, CBR3 TRPA1 3759/4885LMNA 4247/4885CACNA1H 4545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.