Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.43 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252480 | 0.98 | CHRM1 (0.45) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Bromide SCHEMBL8759877 | 0.95 | CHRM1 (0.43) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Methacholine SCHEMBL1536636 | 0.83 | TSHR (0.72) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Hydrochloric Acid SCHEMBL28364686 | 0.80 | MAPT (0.61) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Hydrochloric Acid SCHEMBL1759064 | 0.80 | LMNA (0.48) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Hydrochloric Acid SCHEMBL10633363 | 0.80 | MAPT (0.61) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| SCHEMBL4783813 | 0.77 | CHRM1 (0.59) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| SCHEMBL6512446 | 0.77 | CHRM1 (0.43) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| SCHEMBL27362812 | 0.77 | LMNA (0.47) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Iodide SCHEMBL27443982 | 0.76 | CHRM1 (0.57) | MAPTSMN1; SMN2BLMGALR3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117279681-A | Product delivery device and method | 呼吸解决方案股份有限公司 | 2023-12-22 | — | — | CN | claimed |
| CN-113544121-A | Heterocyclic derivative with beta 2 receptor agonistic and M receptor antagonistic activities and medical application thereof | 中国医药研究开发中心有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2015054253-A1 | METHODS AND COMPOSITIONS FOR GENE CORRECTION USING NUCLEOTIDE-MODIFIED MESSENGER RNA | SANGAMO BIOSCIENCES, INC. (US) | 2015-04-16 | — | — | WO | disclosed |