SCHEMBL16638682

SCHEMBL16638682

CCc1ccc(-c2ccc(Cl)c(CF)c2)cc1C1=C(O)C(C)(C)C(=O)C(C)(C)C1=O

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.32
ACACA Q13085 1/20 0.32
HSD17B1 P14061 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12129359 0.89 ACACB (0.41) ACACBACACAHSD17B1
SCHEMBL12129332 0.87 ACACB (0.36) ACACBACACAHSD17B1
SCHEMBL13273651 0.86 HSD17B1 (0.32) HSD17B1
SCHEMBL12129336 0.86 ACACB (0.38) ACACBACACAHSD17B1
SCHEMBL12129357 0.86 COMT (0.38)
SCHEMBL12129400 0.84 RORC (0.33)
SCHEMBL12129384 0.84 HTR6 (0.32)
SCHEMBL12129377 0.84 AURKA (0.33)
SCHEMBL12129395 0.83 PGR (0.41)
SCHEMBL12129360 0.82 PTGS2 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9006429-B2 Herbicidal pyrandione, thiopyrandione, and cyclohexanetrione derivatives SYNGENTA CROP PROTECTION, LLC (US) 2015-04-14 US disclosed