SCHEMBL16640

SCHEMBL16640

CS(=O)(=O)OCC1CCCO1

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.46
POLB P06746 1/20 0.46
ALDH1A1 P00352 4/20 0.44
SCN9A Q15858 1/20 0.41
PKM P14618 2/20 0.38
CXCR4 P61073 1/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
NR2F2 P24468 1/20 0.37
RAB9A P51151 1/20 0.37
TSHR P16473 1/20 0.37
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL709637 1.00 LMNA (0.46) LMNAPOLBALDH1A1SCN9APKM
SCHEMBL419701 1.00 LMNA (0.46) LMNAPOLBALDH1A1SCN9APKM
SCHEMBL4640252 0.94 LMNA (0.41) LMNAPOLBALDH1A1SCN9ASMN1; SMN2
SCHEMBL709307 0.94 LMNA (0.41) LMNAPOLBALDH1A1SCN9ASMN1; SMN2
SCHEMBL8709127 0.94 LMNA (0.41) LMNAPOLBALDH1A1SCN9ASMN1; SMN2
SCHEMBL20266437 0.90 LMNA (0.36) LMNAPOLBALDH1A1SCN9ATSHR
SCHEMBL12747032 0.90 LMNA (0.36) LMNAPOLBALDH1A1SCN9ATSHR
SCHEMBL26687025 0.84 LMNA (0.49) LMNAPOLBALDH1A1SCN9APKM
SCHEMBL2198401 0.81 ALDH1A1 (0.39) LMNAPOLBALDH1A1SCN9APKM
SCHEMBL15074098 0.81 ALDH1A1 (0.39) LMNAPOLBALDH1A1SCN9APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110068-A1 Lithium secondary cell MITSUBISHI CHEMICAL CORPORATION (JP) 2004-06-10 US claimed
EP-1406338-A1 LITHIUM SECONDARY CELL MITSUBISHI CHEMICAL CORPORATION (JP) 2004-04-07 EP claimed
WO-2025122695-A1 COMBINATION THERAPY COMPRISING DGK INHIBITORS AND PD-1/PD-L1 INHIBITORS INCYTE CORPORATION (US) 2025-06-12 WO disclosed
WO-2025043151-A2 BICYCLIC DGK INHIBITORS INCYTE CORPORATION (US) 2025-02-27 WO disclosed
CN-113121393-B Aromatic amide compound and application thereof in medicines 广东东阳光药业股份有限公司 2024-08-09 CN disclosed
US-20240066027-A1 NOVEL PAR-2 INHIBITORS DOMAIN THERAPEUTICS (FR) 2024-02-29 US disclosed
US-20240051951-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2024-02-15 US disclosed
EP-4255904-A2 NOVEL PAR-2 INHIBITORS Domain Therapeutics (FR) 2023-10-11 EP disclosed
US-20230286965-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-09-14 US disclosed
US-11725001-B2 Bicyclic compound and use thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-08-15 US disclosed
US-20230013903-A1 Electrolytic Solution for Secondary Battery and Lithium Secondary Battery Including the Same SK ON CO., LTD. (KR) 2023-01-19 US disclosed
EP-0389037-B1 N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-09-20 EP disclosed
US-5374637-A Stimulate gastrointestinal motility JANSSEN PHARMACEUTICA N.V. (BE) 1994-12-20 US disclosed
US-5262418-A Laxatives, gastrointestinal disorders TANSSEN PHARMACEUTICA N.V. (BE) 1993-11-16 US disclosed
US-5185335-A Administer to mammals to stimulate gastrointestinal motility JANSSEN PHARMACEUTICA N.V. (BE) 1993-02-09 US disclosed
EP-0445862-A2 N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1991-09-11 EP disclosed
EP-0389037-A1 N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1990-09-26 EP disclosed
EP-0213775-B1 NEW BENZAMIDES WALTON S.A. (ES) 1990-01-03 EP disclosed
US-4772618-A NONAROMATIC CYCLIC (THIO)ETHER GROUPS, AMINE INTERMEDIATES, GASTROINTESTINAL DISORDERS FORDONAL, S.A. (ES) 1988-09-20 US disclosed
EP-0213775-A1 New Benzamides WALTON S.A. (ES) 1987-03-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240051951-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT1 LMNA 1399/4885POLB 2256/4885ALDH1A1 3781/4885
US-20230286965-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT8 LMNA 1468/4885POLB 2109/4885ALDH1A1 4003/4885
US-11725001-B2 Bicyclic compound and use thereof PRMT5, PRMT6, PRMT1 LMNA 1399/4885POLB 2256/4885ALDH1A1 3781/4885
US-20240066027-A1 NOVEL PAR-2 INHIBITORS F2RL1, F2R, F2RL3 LMNA 1935/4885POLB 4651/4885ALDH1A1 1523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.