Sugi Predict

Sugi Predict / Compounds / SCHEMBL709307

SCHEMBL709307

SCHEMBL709307

CS(=O)(=O)OCC1CCCCO1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.39
▸ SCN9A Q15858 1/20 0.38
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ MMP9 P14780 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4640252 1.00 LMNA (0.41) LMNAPOLBALDH1A1SCN9ANPC1
SCHEMBL8709127 1.00 LMNA (0.41) LMNAPOLBALDH1A1SCN9ANPC1
SCHEMBL419701 0.94 LMNA (0.46) LMNAPOLBALDH1A1SCN9ARAB9A
SCHEMBL16640 0.94 LMNA (0.46) LMNAPOLBALDH1A1SCN9ARAB9A
SCHEMBL709637 0.94 LMNA (0.46) LMNAPOLBALDH1A1SCN9ARAB9A
SCHEMBL20266437 0.88 LMNA (0.36) LMNAPOLBALDH1A1SCN9AKDM4E
SCHEMBL12747032 0.88 LMNA (0.36) LMNAPOLBALDH1A1SCN9AKDM4E
SCHEMBL2199578 0.82 ALDH1A1 (0.42) LMNAPOLBALDH1A1RAB9ASMN1; SMN2
SCHEMBL10682980 0.81 CA2 (0.44) LMNAPOLBALDH1A1NPC1RAB9A
SCHEMBL26687025 0.79 LMNA (0.49) LMNAPOLBALDH1A1SCN9ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 — — US disclosed
EP-4385980-A1 INDAZOLES AS INHIBITORS OF NAV1.8 Grünenthal GmbH (DE) 2024-06-19 — — EP disclosed
US-20240051951-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2024-02-15 — — US disclosed
US-20230286965-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-09-14 — — US disclosed
US-11725001-B2 Bicyclic compound and use thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-08-15 — — US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 — — US disclosed
US-20230025025-A1 SUBSTITUTED PYRAZOLE AMIDES GRUENENTHAL GMBH (DE) 2023-01-26 — — US disclosed
WO-2022263498-A1 SUBSTITUTED PYRAZOLE AMIDES Grünenthal GmbH (DE) 2022-12-22 — — WO disclosed
US-20220402902-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. 2022-12-22 — — US disclosed
US-11446261-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2022-09-20 — — US disclosed
EP-2091955-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT Acucela, Inc. (US) 2009-08-26 — — EP disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 — — WO disclosed
WO-2007143847-A1 SPIROTROPANE COMPOUNDS VIROCHEM PHARMA INC. (CA) 2007-12-21 — — WO disclosed
US-6265352-B1 Substituted carbamoyl triazoles and their use as herbicides BASF AKTIENGESELLSCHAFT (DE) 2001-07-24 — — US disclosed
US-5736549-A INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE, USED FOR TREATING OR PREVENTING TISSUE REJECTION OR SELECTIVE SUPPRESSION OF MAMMALIAN T-CELL FUNCTION CHIROSCIENCE LIMITED (GB) 1998-04-07 — — US disclosed
EP-0784624-A1 PURINE AND GUANINE COMPOUNDS AS INHIBITORS OF PNP Chiroscience Limited (GB) 1997-07-23 — — EP disclosed
WO-1996011200-A1 PURINE AND GUANINE COMPOUNDS AS INHIBITORS OF PNP CHIROSCIENCE LIMITED (GB) 1996-04-18 — — WO disclosed
US-4606753-A PLANT GROWTH REGULATORS SHELL OIL COMPANY (US) 1986-08-19 — — US disclosed
US-4588821-A 2-oxabicyclo[2.2.1]heptan-6-ol ether herbicides SHELL OIL COMPANY (US) 1986-05-13 — — US disclosed
US-4525203-A ((3,4,5,6-Tetrahydro-2H-pyran-2-yl)methoxy)oxabicycloalkane herbicides SHELL OIL COMPANY (US) 1985-06-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402902-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT1 LMNA 1399/4885POLB 2256/4885ALDH1A1 3781/4885
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER LMNA 565/4885POLB 1979/4885ALDH1A1 140/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER LMNA 566/4885POLB 2057/4885ALDH1A1 133/4885
US-20240051951-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT1 LMNA 1399/4885POLB 2256/4885ALDH1A1 3781/4885
US-20230286965-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT8 LMNA 1468/4885POLB 2109/4885ALDH1A1 4003/4885
US-11446261-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER LMNA 565/4885POLB 1979/4885ALDH1A1 140/4885
US-11725001-B2 Bicyclic compound and use thereof PRMT5, PRMT6, PRMT1 LMNA 1399/4885POLB 2256/4885ALDH1A1 3781/4885
US-20230025025-A1 SUBSTITUTED PYRAZOLE AMIDES SCN8A, SCN1A, SCN7A LMNA 2843/4885POLB 4395/4885ALDH1A1 834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.