SCHEMBL16640315

SCHEMBL16640315

CC(C)c1ccc(-n2c3ccccc3c3cnccc32)nc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.43
MAOB P27338 4/20 0.43
ACHE P22303 2/20 0.43
CYP2D6 P10635 1/20 0.41
TOP2A P11388 1/20 0.36
MKNK1 Q9BUB5 1/20 0.35
MKNK2 Q9HBH9 1/20 0.35
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
GRM4 Q14833 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
SLC6A2 P23975 1/20 0.32
KDR P35968 2/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16640320 0.92 MKNK1 (0.35) MAOAMAOBACHECYP2D6TOP2A
SCHEMBL16640328 0.90 GRM4 (0.40) MKNK1MKNK2GRM4PTGDR2SMO
SCHEMBL16644610 0.82 MAOA (0.50) MAOAMAOBACHECYP2D6TOP2A
SCHEMBL16640335 0.82 MAOA (0.47) MAOAMAOBACHECYP2D6TOP2A
SCHEMBL16640319 0.81 GRM4 (0.35) GRM4SLC6A2SMO
SCHEMBL16640316 0.81 GRM4 (0.35) GRM4PTGDR2HDAC3HDAC2HDAC6
SCHEMBL15394901 0.80 MAOA (0.48) MAOAMAOBACHECYP2D6TOP2A
SCHEMBL261825 0.80 MAOA (0.48) MAOAMAOBACHECYP2D6TOP2A
SCHEMBL1966693 0.79 G6PD (0.47) MAOAMAOBACHECYP2D6TOP2A
SCHEMBL21453895 0.78 MAOA (0.43) MAOAMAOBACHECYP2D6TOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11189808-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-11-30 US disclosed
US-20200152891-A1 PLATINUM COMPLEXES AND DEVICES UNIV ARIZONA STATE (US) 2020-05-14 US disclosed
US-10566553-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-02-18 US disclosed
US-9947881-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-04-17 US disclosed
US-9947881-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-04-17 US disclosed
US-20170012224-A1 PLATINUM COMPLEXES AND DEVICES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-01-12 US disclosed
US-9385329-B2 Platinum complexes and devices Arizona Board of Regents on behalf of Arizona State University and Universal Display Corporation (US) 2016-07-05 US disclosed
US-20150105556-A1 PLATINUM COMPLEXES AND DEVICES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2015-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11189808-B2 Platinum complexes and devices OXA1L, OCIAD1, OCIAD2 MAOA 1850/4885MAOB 1214/4885ACHE 3544/4885
US-10566553-B2 Platinum complexes and devices OXA1L, OCIAD1, OCIAD2 MAOA 1850/4885MAOB 1214/4885ACHE 3544/4885
US-20200152891-A1 PLATINUM COMPLEXES AND DEVICES OXA1L, OCIAD1, OCIAD2 MAOA 1850/4885MAOB 1214/4885ACHE 3544/4885
US-20170012224-A1 PLATINUM COMPLEXES AND DEVICES OXA1L, OCIAD1, OCIAD2 MAOA 1850/4885MAOB 1214/4885ACHE 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.