SCHEMBL16640328

SCHEMBL16640328

CC(C)c1ccc(-n2c3ccccc3c3ccccc32)nc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 1/20 0.40
KDM4E B2RXH2 2/20 0.37
ATM Q13315 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
GPR3 P46089 1/20 0.35
SMO Q99835 1/20 0.35
POLB P06746 2/20 0.34
ALDH1A1 P00352 2/20 0.34
EGLN1 Q9GZT9 1/20 0.33
ACACB O00763 1/20 0.33
KIF11 P52732 1/20 0.33
PTGER4 P35408 2/20 0.33
USP14 P54578 1/20 0.32
MKNK1 Q9BUB5 1/20 0.32
MKNK2 Q9HBH9 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
HPGD P15428 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16640320 0.90 MKNK1 (0.35) GRM4MKNK1MKNK2PTGDR2
SCHEMBL16640315 0.90 MAOA (0.43) GRM4SMOMKNK1MKNK2PTGDR2
SCHEMBL16640316 0.87 GRM4 (0.35) GRM4KDM4EATML3MBTL1SMO
SCHEMBL16640319 0.87 GRM4 (0.35) GRM4KDM4EATML3MBTL1SMO
SCHEMBL16547031 0.77 GRIN2D (0.44) GRM4KDM4EATML3MBTL1GPR3
SCHEMBL19860219 0.77 RORA (0.40) POLBALDH1A1KIF11NPC1RAB9A
SCHEMBL21726279 0.77 FFAR4 (0.35)
SCHEMBL612189 0.77 KDM4E (0.43) GRM4KDM4EATML3MBTL1GPR3
SCHEMBL18910336 0.75 SMN1; SMN2 (0.37) GRM4KDM4EATML3MBTL1GPR3
SCHEMBL15394888 0.75 KDM4E (0.52) GRM4KDM4EATML3MBTL1GPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230157154-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-05-18 US disclosed
US-11189808-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-11-30 US disclosed
US-20200152891-A1 PLATINUM COMPLEXES AND DEVICES UNIV ARIZONA STATE (US) 2020-05-14 US disclosed
US-10566553-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-02-18 US disclosed
US-9947881-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-04-17 US disclosed
US-9947881-B2 Platinum complexes and devices ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-04-17 US disclosed
US-20170012224-A1 PLATINUM COMPLEXES AND DEVICES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-01-12 US disclosed
US-9385329-B2 Platinum complexes and devices Arizona Board of Regents on behalf of Arizona State University and Universal Display Corporation (US) 2016-07-05 US disclosed
US-20150105556-A1 PLATINUM COMPLEXES AND DEVICES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2015-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11189808-B2 Platinum complexes and devices OXA1L, OCIAD1, OCIAD2 GRM4 3031/4885KDM4E 4835/4885ATM 1739/4885
US-10566553-B2 Platinum complexes and devices OXA1L, OCIAD1, OCIAD2 GRM4 3031/4885KDM4E 4835/4885ATM 1739/4885
US-20230157154-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LIFR, SOD1, GLRA3 GRM4 324/4885KDM4E 3127/4885ATM 3463/4885
US-20200152891-A1 PLATINUM COMPLEXES AND DEVICES OXA1L, OCIAD1, OCIAD2 GRM4 3031/4885KDM4E 4835/4885ATM 1739/4885
US-20170012224-A1 PLATINUM COMPLEXES AND DEVICES OXA1L, OCIAD1, OCIAD2 GRM4 3031/4885KDM4E 4835/4885ATM 1739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.