Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | FGF1 | P05230 | 2/20 | 0.41 |
| ▸ | FGF2 | P09038 | 2/20 | 0.41 |
| ▸ | VEGFA | P15692 | 2/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CD209 | Q9NNX6 | 2/20 | 0.40 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509354 | 0.93 | MMP13 (0.48) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL18056168 | 0.92 | MMP13 (0.42) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL18164150 | 0.92 | MMP13 (0.42) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL30891378 | 0.89 | MMP13 (0.46) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL19860816 | 0.89 | MMP13 (0.46) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL16628168 | 0.89 | MMP13 (0.46) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL18164176 | 0.89 | MMP13 (0.47) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL16640842 | 0.89 | MMP13 (0.47) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL16640802 | 0.89 | MMP13 (0.47) | MMP13FGF1FGF2VEGFAHPSE | |
| SCHEMBL16640798 | 0.89 | MMP13 (0.47) | MMP13FGF1FGF2VEGFAHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | US | disclosed |
| US-9427475-B2 | Glucose-responsive insulin conjugates | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150105317-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME LLC | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105317-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | MMP13 3215/4885FGF1 611/4885FGF2 462/4885 |
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | MMP13 3215/4885FGF1 611/4885FGF2 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.